Lessons in Chemistry cast: who's who in the 1950s drama

Lessons in Chemistry cast Lewis Pullman as Calvin Evans and Brie Larson as Elizabeth Zott in a rowing boat.
Lessons in Chemistry cast Lewis Pullman as Calvin Evans and Brie Larson as Elizabeth Zott. (Image credit: Apple TV+)

Lessons in Chemistry, based on the hugely successful 2022 debut novel by Bonnie Garmus, is a must-see Apple TV Plus drama set in America in the late 1950s and early 1960s. 

The series follows brilliant chemist Elizabeth Zott who is fired from her job in a lab when she becomes a young, single mother to her daughter Madeline. Instead, she takes a job hosting Supper at Six which becomes a much-loved cooking show. 

To the frustration of her boss, Elizabeth includes scientific information in the show, which is a surprise hit with both women and men, and her passion ignites something in the millions of suppressed housewives around the country. 

But who's who in this drama adaptation? Here's everything you need to know about the Lessons in Chemistry cast... 

Brie Larson as Elizabeth Zott

Brie Larson in Apple TV Plus' Lessons in Chemistry

Brie Larson as Elizabeth Zott.  (Image credit: Apple)

Brie Larson plays determined TV host and talented chemist Elizabeth Zott. Elizabeth isn't like other women around her, instead, she is trying to make her voice heard in a sexist 1950s world. However, her dream of being a chemist is put on hold when she finds herself pregnant, alone, and fired from her lab - and soon her life is taking a new direction that no one could have predicted. 

Where have you seen Brie Larson before? 

Brie played Carol Danvers in Marvel films Avengers: Endgame and Captain Marvel and took on the lead role of Jeanette in The Glass Castle in 2017. Brie has also starred in Raising Dad, 21 Jump Street, Kong: Skull Island and Just Mercy. 

Lewis Pullman as Calvin Evans 

Lewis Pullman as Calvin Evans.

Lewis Pullman as Calvin Evans. (Image credit: Apple TV+)

Starring alongside Brie Larson is Lewis Pullman as Elizabeth's love interest, Calvin Evans. As well as being a brilliant chemist himself, Calvin isn't like the other men at Hastings Research Institute and believes in Elizabeth's brilliance and worth. Soon the pair strike up a romance that will change the course of their lives forever. 

Where have you seen Lewis Pullman before?

Lewis is known for his roles in the blockbuster movie Top Gun: Maverick and Prime Video show Outer Range. He has also starred in The Strangers: Prey at Night and is soon to take the lead role in a film adaptation of Stephen King's Salem's Lot. 

Aja Naomi King as Harriet Sloane

Aja Naomi King in "Lessons in Chemistry,"

Aja Naomi King as Harriet Sloane. (Image credit: Apple TV Plus)

Aja Naomi King plays Elizabeth's neighbor, Harriet Sloane. The pair start as two people who simply live on the same street, but they quickly bond after a shocking turn of events pushes them together. Soon the women become firm friends as Harriet helps first-time mum and sleep-deprived Elizabeth look after her and Calvin's daughter, Madeline. 

Where have you seen Aja Naomi King before?

Aja Naomi King is best known for her role in How to Get Away with Murder.

 Kevin Sussman as Walter Pine

Stephanie Koenig, Kevin Sussman and Brie Larson in "Lessons in Chemistry,"

Kevin Sussman as Walter Pine.  (Image credit: Apple TV Plus)

American actor and comedian Kevin Sussman plays Walter Pine, the over-worked producer at KCTV who offers Elizabeth a job working on the new TV show, Supper At Six. Although at first Walter is a typical 1950s man who believes that women can't be both beautiful and brilliant, he soon changes his mind when he meets Elizabeth and realizes she is someone unique. 

Where have you seen Kevin Sussman before?

Kevin Sussman is best known for his roles as Walter in Ugly Betty and as Stuart Bloom in The Big Bang Theory.

 Stephanie Koenig as Fran Frask

Stephanie Koenig in "Lessons in Chemistry,"

Stephanie Koenig as Fran Frask. (Image credit: Apple TV Plus)

Stephanie Koenig plays Fran Frask, a secretary working at Hastings Research Institute. Fran and Elizabeth couldn't be more different, while Elizabeth is pushing the boundaries, Fran is unlikeable and finds Elizabeth insufferable. 

Where have you seen Stephanie Koenig before?

Stephanie Koenig is known for her roles in The Flight Attendant, The Offer, Good Luck With Everything and The Spy Movie.

Who else stars in Lessons in Chemistry? 

  • Alice Halsey as Madeline Evans Zott, Elizabeth and Calvin's daughter
  • Patrick Walker as Wakely, a former classmate of Calvin’s
  • Thomas Mann as Boryweitz, Elizabeth's colleague at Hastings Research Institute
  • Beau Bridges as Wilson, a connection from Calvin's past 
  • Rainn Wilson as Phil Lebensmal, KCTV’s executive producer 
  • Ashley Monique Clark as Martha Wakeley
  • Derek Cecil as Dr. Robert Donatti, Elizabeth’s boss at Hastings Research Institute
  • Six-Thirty, Calvin and Elizabeth's talking dog! 
  • Andy Daly as Dr. Price 
  •  Joy Jacobson as Shari

Lessons In Chemistry is now available worldwide on Apple TV Plus. 

Claire Crick
Assistant Managing Editor at What To Watch

Claire is Assistant Managing Editor at What To Watch and has been a journalist for over 15 years, writing about everything from soaps and TV to beauty, entertainment, and even the Royal Family. After starting her career at a soap magazine, she ended up staying for 13 years, and over that time she’s pulled pints in the Rovers Return, sung karaoke in the Emmerdale village hall, taken a stroll around Albert Square, and visited Summer Bay Surf Club in sunny Australia. 

After learning some tricks of the trade at websites Digital Spy, Entertainment Daily, and Woman & Home, Claire landed a role at What’s On TV and whattowatch.com writing about all things TV and film, with a particular love for Aussie soaps, Strictly Come Dancing and Bake Off

She’s interviewed everyone from June Brown — AKA Dot Cotton — to Michelle Keegan, swapped cooking tips with baking legend Mary Berry backstage at the NTAs, and danced the night away with soap stars at countless awards bashes. There’s not a lot she doesn’t know about soaps and TV and can be very handy when a soapy question comes up in a pub quiz! 

As well as all things soap-related, Claire also loves running, spa breaks, days out with her kids, and getting lost in a good book.