The actress, who is married to the Australian former Leeds United and Liverpool star Harry Kewell, said she was excited to be going back to work.
She told Hello! magazine: "It's just kicked in that it's actually happening. I'm going back to work. The kids don't remember me on Emmerdale, so they're excited about seeing mummy on TV.
"The last thing I did was Hollyoaks and I was really nervous. I feel a bit like that on Neighbours, not necessarily because they watch English soaps but more because it's, 'Oh, that's Harry Kewell's wife - what's she doing?'."
The mother of four considers Melbourne a second home after settling here with her family from 2011 to 2013, when her husband played for Melbourne Heart football team.
“I just feel like I’m coming home again. To be able to work in Melbourne for such an iconic soap is a real dream come true. Melbourne is a fantastic city with great weather, people and restaurants, what more could you need,” said Sheree who arrived in Melbourne last week to prepare for the six-week role.
“I’m really looking forward to taking in Melbourne’s great coffee houses; they’re amazing and catching up with friends for a night out in St Kilda.”
Sheree will play British businesswoman Dakota Davies, who also happens to be an old flame of one of Neighbours' male residents and she hasn’t quite recovered from their break-up.
“I’ve been watching Neighbours since the very beginning so to grow up watching a show and to now be part of it is unbelievable. Neighbours is a huge part of the Australian culture just like our soaps in the UK,” said Sheree who has starred in Hollyoaks and Emmerdale.
Sheree's husband Harry recently retired from the game, playing his last match in his hometown of Sydney.
He said he had no regrets about stopping playing: "Overall, I got the fairytale ending - I got to walk out with my kids and play against my hometown team. It's not down to me now - it's down to the next generation of Australian footballers to prove themselves."
The couple divide their time between Australia and the UK and Sheree admitted it could be difficult.
She said: "The rewards are great and I would never complain, but it's just missing your best mate.
"You have to work as a team. If you're both fighting for the spotlight or a big career, I can see that's how relationships can break down. You have to have a bit of give and take. We always wanted one of us to be at home with the kids and said that once Harry retired I would go back to work.
"Harry has almost been pushing me out the door encouraging me to do stuff. He's really supportive. It's all about juggling and making sure you make people happy - that's the most important thing. You can't buy happiness."
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