Big Mouth season 6: episode guide, cast and everything we know about the animated adult series

Maury and Connie the hormone monsters in a minor disagreement in Big Mouth season 6
Big Mouth season 6 (Image credit: Netflix)

Big Mouth has easily become one of Netflix’s most popular adult animated sitcoms. For five straight seasons, series creators Nick Kroll, Andrew Goldberg and Jennifer Flackett have managed to take the usually awkward topic of puberty and turn it into a comedy that continues to draw big names to guest star on the show. 

Now into the series’ sixth season, it appears the comedy, while continuing to focus on the storylines of Jessi, Andrew, Nick, Jay and Missy, actually goes even further into the lives of everyone’s favorite hormone monsters, Maury and Connie. This makes complete sense given when viewers last saw Maury, he was pregnant. (It also makes sense in light of the success of the spinoff series Human Resources, which was a show focused on the characters behind human emotions and sexuality). 

So what can viewers look forward to in the new episodes? Here’s everything we know about Big Mouth season 6.  

Big Mouth season 6 episode guide

Big Mouth season 6 premiered on Friday, October 28 on Netflix. Below we've provide an episode guide for the new 10-episode season. 

Episode 1: "The Hookup House"
"After being snowed in with their families, the restless friends flock to Bridgeton’s latest make-out spot. A new classmate catches Missy’s eye." 

Episode 2: "Twenty Two and You"
"A DNA test leads Nick to uncover a wee family secret. Jay insists on introducing Matthew to the Bilzerian clan. Andrew puts his lovebug to the test." 

Episode 3: "Vagina Shame"
"From itching to grooming to late blooming: There’s no shortage of fodder for shame maven Rita St. Swithens in this special episode." 

Episode 4: "Rice Purity Test"
"A viral quiz about naughty deeds sparks arguments and unlikely new friendships. Matthew plans a baby shower for Maury." 

Episode 5: "Andrew’s Gonna Touch A Boob Tonight"
"While Andrew prepares for a momentous evening with Bernie, Nick sets out to meet his secret grandfather, and Jay cooks up some romance for Matthew." 

Episode 6: "The Apple Brooch"
"The voice of a slick, new tech accessory hypnotizes people into doing things they wouldn’t normally do. Missy grapples with the concept of sin." 

Episode 7: "Dadda Dia!"
"Lola hits the jackpot — in more ways than one. Missy takes her dad Elijah’s church. The Birches make a plan to get rid of their new housemate." 

Episode 8: "Asexual Healing"
"Elijah tries to figure out why he doesn’t have the same sexual urges as his friends. A jealous Andrew hops a train to Vermont to surprise Bernie." 

Episode 9: "The Parents Aren’t Alright"
"While Andrew and Nick deal with parental crises, Jessi meets her new sibling and Matthew realizes he’s made Jay into a different person." 

Episode 10: "F**ked Up Friday"
"A sudden outbreak of body-swapping yields awkward situations and poignant revelations galore." 

What is Big Mouth season 6 about? 

Fans of the series will recall that season 5 ended with Jay breaking things off with Lola to be with Matthew,  Missy finally coming into her own identity, Nick mending things with Jessi after she rejected him and Andrew continuing on as his unashamed and gross self. Oh, and if you’ve watched Human Resources, then you also know Connie and Maury are expecting a baby. Sounds like there will be plenty that’s explored in the new episodes. 

Netflix describes season 6 by stating: 

"The new season of Big Mouth brings a whole new focus on family to the show — whether that means the people you’re biologically related to or those you choose as your community. Inspired by the childhood experiences of co-creators Nick Kroll and Andrew Goldberg, season 6 will continue to follow the Hormone Monsters as they navigate adolescence, this time unpacking the concept that while you can’t pick your blood family, you can surround yourself with people who love you just the way you are."

Big Mouth season 6 cast

Maury and Matthew in the school gym in Big Mouth season 6

Maury and Matthew, Big Mouth season 6 (Image credit: Netflix)

Back to reprise her role as Connie is none other than SNL alum Maya Rudolph. Of all the voiceover actors featured in the series, Rudolph is the only one to receive two Emmys for her work. Following Big Mouth season 6, she’ll be spotted in the long-awaited sequel Disenchanted

Joining Rudolph in the new season is of course Big Mouth creator Nick Kroll. Kroll voices at least 27 characters in the series, including that of Nick Birch, Maury, Coach Steve and Lola,  just to name a few. 

Here is a list of the big names featured in the new episodes. 

  • Maya Rudolph as Connie the Hormone Monstress  
  • Nick Kroll as Nick Birtch, Mauy the Hormone Monster, Coach Steve, etc.   
  • John Mulaney as Andrew Glouberman   
  • Jason Mantzoukas as Jay Bilzerian   
  • Ayo Edebiri as Missy Foreman-Greenwald    
  • Jessi Klein as Jessi Glaser   
  • Jordan Peele as the Ghost of Duke Ellington   
  • Andrew Rannells as Matthew MacDell    
  • Richard Kind as Marty Glouberman   
  • June Diane Raphael as Devin LeSeven  
  • Paula Pell as Barbara Glouberman  
  • Jak Knight as DeVon  
  • Fred Armisen as Elliot Birch 

Also slated to join the season as guest stars are Adam Levine (The Voice), Brian Tyree Henry (Atlanta), Jeff Goldblum (Jurrasic World: Dominion)  and Tyler the Creator. 

To check out the full cast, make sure you read our Meet the Big Mouth season 6 cast piece. 

Big Mouth season 6 trailer

Check out the season 6 trailer. It certainly seems the show is staying on brand. We can't wait to see what happens with Maury and Connie's expanding family. 

How to watch Big Mouth

Big Mouth is a Netflix Original series. Those interested in watching new episodes will need to have a subscription to Netflix. Currently, the streaming service offers several options for would-be subscribers.  

Terrell Smith

Terrell Smith has a diverse writing background having penned material for a wide array of clients including the federal government and Bravo television personalities.  When he’s not writing as Terrell, he’s writing under his pseudonym Tavion Scott, creating scripts for his audio drama podcasts. Terrell is a huge fan of great storytelling when it comes to television and film. Some of his favorite shows include The CrownWandaVision, Abbot Elementary and Godfather of HarlemAnd a fun fact is he's completely dialed into the TLC 90 Day Fiancé universe.